Therapeutic efficacy of compound matrine injection combined with Fentanyl transdermal patch on cancer pain in elderly patients with advanced gastric cancer
10.3760/cma.j.issn.0254-9026.2017.06.018
- VernacularTitle:复方苦参注射液和芬太尼透皮贴剂联合治疗老年晚期胃癌癌性疼痛的疗效
- Author:
Jing WANG
;
Rong TAO
;
Guangyin WU
;
Lingjie XIA
- Keywords:
Matrine;
Fentanyl;
Advanced gastric cancer;
Carcinoma pain
- From:
Chinese Journal of Geriatrics
2017;36(6):677-679
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of compound matrine injection combined with fentanyl transdermal patch in the treatment of elderly patients with advanced gastric cancer.Methods A total of 100 elderly patients with advanced gastric cancer were enrolled in this study.All patients were randomly divided into the observation group (n =50) given compound matrine injection plus Fentanyl transdermal patch and the control group given fentanyl transdermal patch alone(n=50).The analgesic efficacy,quality of life and adverse reaction were evaluated and compared between the two groups.Results The analgesic efficacy was significantly higher in the observation group[76％(38/50)]than in the control group[(44％),(x2=4.46,P＜0.05)].Before treatment,the life quality scores were similar between two groups.After treatment,the life quality score of the two groups was significantly improved as compared with pre-treatment.In addition,life quality score was significantly higher in the observation group than in control group(t=8.61,P＜0.05).After treatment,only mild adverse events were observed in two groups,with no significant difference in adverse events between the two groups(x2 =0.00,P＞0.05).Conclusions Compound matrine injection plus Fentanyl transdermal patch are safe and effective in the treatment of carcinoma pain in elderly patients with advanced gastric cancer.
