Effects Observation of Preemptive Analgesia of Parecoxib-sodium for Radical Mastectomy of Breast Cancer
10.6039/j.issn.1001-0408.2017.18.17
- VernacularTitle:帕瑞昔布钠超前镇痛用于乳腺癌患者根治术的效果观察
- Author:
Donghai LYU
;
Zhongyi WANG
;
Tongjun ZHANG
;
Hongxu JIN
;
Shuangyou SHI
- Keywords:
Parecoxib-sodium;
Radical operation of breast cancer;
Preemptive analgesia;
Patient controlled intravenous analge-sia;
Safety
- From:
China Pharmacy
2017;28(18):2506-2508
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of preemptive analgesia of parecoxib-sodium for radical mastectomy of breast cancer. METHODS:A total of 60 female patients underwent selective radical mastectomy of breast cancer under general anes-thesia were randomly divided into observation group(40 cases)and control group(20 cases). 15 min before anesthesia induction, observation group was given intravenous injection of Parecoxib-sodium for injection 40 mg. Control group was given intravenous in-jection of 0.9% Sodium chloride injection 5 mL. The pain visual analogue scale(VAS),the frequency of patient controlled intrave-nous analgesia(PCA)and ADR were observed between 2 groups at different time points after surgery. RESULTS:VAS scores of observation group were significantly lower than those of control group 2,4,6,8 h after operation,and the frequency of PCA 0-4, 4-12,12-24,24-36 h after operation was significantly lower than control group,with statistical significance(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS:The preemptive analgesia of parecoxib-sodium can effectively reduce pain degree of patients with breast cancer after radical mastectomy,the frequency of PCA, and do not increase the occurrence of ADR.
