Comparison of Effectiveness and Safety of Low-molecular-weight-heparin and Rivaroxaban in Preventing Lower Extremity Deep Vein Thrombosis in the Elderly Patients after Surgery of Replacement of Fracture
10.6039/j.issn.1001-0408.2017.18.09
- VernacularTitle:低分子肝素与利伐沙班预防老年患者骨折置换术后双下肢深静脉血栓的有效性和安全性比较
- Author:
Huiping LU
;
Yanru LIU
;
Peipei GAO
;
Jingru GONG
- Keywords:
Low-molecular-weight-heparin;
Rivaroxaban;
Deep vein thrombosis;
Surgery of replacement of fracture;
Therapeu-tic efficacy;
Safety
- From:
China Pharmacy
2017;28(18):2480-2482
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the effectiveness and safety of low-molecular-weight-heparin(LMWH)calcium and rivar-oxaban in preventing lower extremity deep venous thrombosis (DVT) in the elderly patients after surgery of replacement of frac-ture. METHODS:A total of 58 elderly patients underwent hip or artificial femoral head replacement were randomly divided into LMWH group (29 cases) and Rivaroxaban group (29 cases). All patients received basic prevention and physical prevention for DVT after surgery. Based on this,LMWH group was given Heparin calcium injection 4100 IU subcutaneously 10 h after surgery, for 10 d. Rivaroxabar group was given Rivaroxaban tablet 10 mg 10 h after surgery,once a day,for consecutive 10 d. The occur-rence of DVT and positive D-dimer were observed in 2 groups after surgery. The PT,APTT,TT,FIB and platelet counts abnormal-ity were also observed in 2 groups. RESULTS:There was no statistical significance in the incidence of DVT,the occarrence of pos-itive D-dimer,PT,APTT,TT,FIB and platelet counts abnormality 4,10 d after surgery between 2 groups(P>0.05). CONCLU-SIONS:LMWH and rivaroxaban both can be used for lower extremity DVT in the elderly patients after replacement of fracture sur-gery of and have similar therapeutic efficacy and safety.
