Expression and Clinical Significance of miR-143 in Esophageal Squamous Cell Carcinoma and Esophageal Intraepithelial Neoplasia
10.3969/j.issn.1008-7125.2017.06.008
- VernacularTitle:miR-143在食管鳞癌和上皮内瘤变组织中的表达及其临床意义
- Author:
Zhimei ZHANG
;
Xiaoyan HE
;
Ruihua SHI
- Keywords:
MicroRNAs;
Carcinoma;
Squamous Cell;
Intraepithelial Neoplasia
- From:
Chinese Journal of Gastroenterology
2017;22(6):364-366
- CountryChina
- Language:Chinese
-
Abstract:
Studies have shown that microRNA plays a role of oncogene or tumor suppressor gene in the carcinogenesis and progression of tumor.However, the role of microRNA-143 (miR-143) in esophageal squamous cell carcinoma (ESCC) needs further study.Aims: To investigate the expression and clinical significance of miR-143 in ESCC.Methods: Sixty-three ESCC tissues and corresponding para-cancerous tissues, 40 esophageal intraepithelial neoplasia (IEN) tissues and corresponding normal tissues from Jan.2013 to Dec.2013 at the First Affiliated Hospital with Nanjing Medical University were enrolled.The expression of miR-143 was examined by real-time quantitative PCR, and its correlations with clinicopathological features were analyzed.Results: Compared with controls, expression of miR-143 was down-regulated in ESCC and IEN (P<0.05).Expression of miR-143 was correlated with pathological type (P<0.001), but not with gender and age (P>0.05).Expression of miR-143 was correlated with pathological staging, lymph node metastasis and TNM staging (P<0.05), but not correlated with tumor infiltration depth in ESCC patients (P>0.05).Conclusions: Expression of miR-143 is down-regulated in ESCC and IEN tissues, which may be closely related to the development and progression of ESCC, and has the potential to be used as a new target for diagnosis of ESCC.
