Analysis on correlation between serum pentraxin 3 and metabolic indices in patients with type 2 diabetes mellitus
10.3969/j.issn.1671-8348.2017.16.019
- VernacularTitle:2型糖尿病患者血清正五聚蛋白3与代谢指标相关性的分析
- Author:
Jianshen YU
;
Hua YANG
;
Xiaodong YANG
;
Lihua RAO
;
Yuntao LIU
- Keywords:
pentraxin3;
type 2 diabetes mellitus;
body mass index
- From:
Chongqing Medicine
2017;46(16):2221-2223
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of serum pentraxin3 level in different body mass indices groups among the patients with type 2 diabetes mellitus(T2DM) and to analyze its correlation with metabolic indices.Methods A total of 164 T2DM patients were divided into the normal body mass group (A,n=53),over-weight group (B,n=56) and obese group(C,n=55) according to BMI.Serum pentraxin3 level was assayed by ELISA.Then the relationship between serum pentraxin3 levels with BMI.blood glucose,blood lipid andHOMA-IR was analyzed.Results The pentraxin3 levels in the group A,B and C were (3.46±0.19),(2.47 ± 0.21),(1.44 ± 0.18) ng/mL respectively,the pairwise comparison among three groups showed the statistical difference (P＜0.05).The pentraxin3 level was negatively correlated with BMI,TG,LDL-C,FINS and HOMA-IR (r=-0.897,0.621,-0.232,-0.593,-0.487,P＜0.05 or P＜0.01).The multiple stepwise regression analysis showed that BMI and HOMA-IR were independently correlated with serum pentraxin31evel.Conclusion BMI and HOMA-IR are the independent risk factor for af fecting serum pentraxin3 level in T2DM patients.
