Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity.
- Author:
Philip PRINZ
1
;
Andreas STENGEL
Author Information
- Publication Type:Review
- Keywords: Bariatric surgery; Brain-gut axis; Deep brain stimulation; Psychosomatic; Obesity
- MeSH: Appetite; Bariatric Surgery; Cholecystokinin; Deep Brain Stimulation; Eating*; Gastrointestinal Tract; Ghrelin; Glucagon-Like Peptide 1; Obesity*; Peptide YY; Peptides*
- From:Journal of Neurogastroenterology and Motility 2017;23(2):180-196
- CountryRepublic of Korea
- Language:English
- Abstract: This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative—physical activity and pharmacotherapy—treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways.
