Analysis of Urinary Metabonomics Pathway in Rats with Chronic Glomerulonephritis Intervened by Tannins from Pericarpium Granati
- VernacularTitle:石榴皮鞣质改善慢性肾小球肾炎大鼠的尿液代谢组学的通路分析
- Author:
Peng CHEN
;
Jie TU
;
Benhong ZHOU
- Keywords:
Urine metabonomics;
Chronic glomerulonephritis;
Pericarpium Granati;
Metabolic pathway
- From:
China Pharmacist
2017;20(6):969-973,993
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the metabolicomics pathway in the rats with chronic glomerulonephritis intervened by tannins from Pericarpium Granati.Methods: Signal pathway analysis was carried out using the KEGG database and molecular metabolite annotation was performed using HMDB database.The enzyme or transporter and its related properties were analyzed.The metabolite path visualization was carried out by using MetPA network software.Results: The analysis of biological metabolism pathway showed that 12 metabolites involved in 16 metabolic pathways.The pathway of tryptophan metabolism, citrate cycle, phenylalanine metabolism, cysteine and methionine metabolism showed notable changes (P<0.05).Conclusion: The changes of phenylalanine metabolism, citrate cycle, tryptophan metabolism, cysteine and methionine metabolism in the rats with chronic glomerulonephritis intervened by tannins from Pericarpium Granati participate the pathological process.
