Inclusion Process Optimization of Bupleurum Volatile Oil in Xiao' er Jiegan Particle by Orthogonal Test
- VernacularTitle:正交试验法优选小儿解感颗粒中柴胡挥发油的包合工艺
- Author:
Xin XU
;
Dongmei ZHU
;
Dayong LIU
;
Wencui YANG
;
Huanxia HUANG
;
Jie LIU
- Keywords:
Xiao'er Jiegan particle;
Bupleurum chinense DC.;
Volatile oil;
Inclusion process;
Orthogonal test
- From:
China Pharmacist
2017;20(6):985-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To optimize the inclusion process of volatile oil in Xiao' er Jiegan particle.Methods: β-Cyclodextrin was used as the inclusion material.Orthogonal experiments were performed,and the yield of volatile oil inclusion complex and the inclusion rate of volatile oil were taken as the indices to study the influence of inclusion temperature, inclusion time and the ratio of β-cyclodextrin to volatile oil (g∶ml) on the inclusion process.The β-CD-volatile oil inclusion complex was added to Xiao' er Jiegan particle and the stability studies were conducted as well.Results: The optimum volatile oils inclusion process of Xiao'er Jiegan particle was as follows: the inclusion temperature was 40℃, the inclusion time was 3 h , and the ratio of β-cyclodextrin to volatile oil (g∶ml) was 8∶1.The loss of volatile oil prepared by direct injection method was 51.27% after 6-month storage at room temperature, while that prepared by the inclusion method was only 3.13% after 24-month storage at room temperature.Conclusion: The optimized inclusion process of volatile oil is reasonable and feasible, and the stability of the prepared particle is also promising.
