Pharmacodynamics of Modified Xiaochaihutang Granules and Its Active Ingredients Group on Gastric Ulcer
- VernacularTitle:加味小柴胡汤颗粒及其有效部位组方抗胃溃疡的药效研究
- Author:
Wei LIU
;
Mengling YANG
;
Xuejian CHEN
;
Aijun ZHOU
;
Shuhe CHEN
;
Yanwen LIU
- Keywords:
Modified Xiaochaihutang granules;
Active ingredients group;
Gastric ulcer model;
Ulcer index
- From:
China Pharmacist
2017;20(6):1031-1034
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the pharmacodynamics of modified Xiaochaihutang granules (MXG) and its active ingredients group (AIG) on gastric ulcer in order to provide scientific basis for the clinical effect and lay foundation for the development of related hospital preparations.Methods: Gastric ulcer models induced by pyloric ligation,acetic acid and ethanol were applied to observe the curative effects of MXG and its AIG, and the effects of MXG and its AIG on gastric secretion, gastric acid content, pepsin activity, superoxide dismutase (SOD) and malondialdehyde(MDA) contents were also studied.Results: Compared to the model control group,MXG and AIG could significantly reduce the ulcer index(P<0.01), total acidity(P<0.01),and pepsin activity (P<0.05 or 0.01), increase the SOD activity (P<0.05)and inhibit the increase of lipid peroxide MDA.Conclusion: MXG and AIG show better control effects on acute and chronic gastric ulcer, and the effects are related to reducing the activity of pepsin, increasing the SOD activity, inhibiting the increase of lipid peroxide MDA and so on.
