Retrospective Study on the Conversion Coefficient of High Dose of Morphine Injection Continuous PCA Pump Delivery for the Patients with Advanced Cancer Pain
- VernacularTitle:晚期癌痛患者大剂量吗啡持续PCA泵给药转换系数的回顾性研究
- Author:
Yong YANG
;
Lige WU
;
Yonggang LIU
;
Xudong ZHANG
;
Di DENG
- Keywords:
Morphine injection;
Opioid conversion;
Conversion coefficient;
Self-control analgesia pump;
Advanced cancer pain
- From:
China Pharmacist
2017;20(6):1061-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To discuss the conversion coefficient of morphine injection with continuous intravenous pump delivery or subcutaneous injection for the patients with advanced cancer pain demanding high dose of opioids.Methods: Using a retrospective survey, the patients with advanced cancer pain demanding high dose of opioids with poor efficacy were divided into 3∶1 group and 2.5∶1 group, and the conversion coefficient of 3∶1 or 2.5∶1 was used for the opioids equivalently conversed to intravenous or subcutaneous injection of morphine.After the conversion, the degree of pain relief, the analgesic efficiency in the conversion process, titration time, daily oral morphine equivalent amount at stable pain, morphine related adverse reactions and the other indicators were studied to evaluate the analgesic effect of morphine injection with different conversion coefficient.Results: There was no statistical significant difference between the two groups in the degree of pain relief, the effective rate of analgesia and the daily oral akministration amount of morphine at sable pain(P>0.05).The adjustment times for morphine in the two groups was (1.57±0.93) and (1.0±0.00), respectively, and the difference was statistically significant (P<0.05).The daily oral administration amount of morphine at stable pain in the two groups respectively was (226.67±69.74) mg and (258.67±101.34) mg;the morphine related adverse reactions were mainly constipation, and there was no significant difference in the incidence (P>0.05).Conclusion: Giving morphine injection to the patients with terminal cancer pain demanding high dose of opioids with poor effect, the use of PCA pump through intravenous or subcutaneous injection can effectively relieve pain.Using the conversion coefficient of 2.5:1 can quickly complete the titration process, and safely achieve the effective analgesia.
