Efficacy Observation of Xuebijing Combined with Bronchoalveolar Lavage in the Adjunctive Therapy of Severe Pulmonary Infection
- VernacularTitle:血必净联合支气管肺泡灌洗辅助治疗重症肺部感染
- Author:
Huiyan ZHANG
- Keywords:
Xuebijing;
Bronchoalveolar lavage;
Severe pulmonary infection;
Inflammatory cytokines
- From:
China Pharmacist
2017;20(6):1071-1073
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the efficacy and safety of Xuebijing combined with bronchoalveolar lavage in the adjunctive therapy of severe pulmonary infection.Methods: Totally 110 patients with severe pulmonary infection were randomly divided into the control group and the observation group according to the admission odd or even number with 55 ones in each.The control group was treated with bronchial lavage on the basis of the conventional therapy.The observation group was treated with Xuebijing combined with bronchoalveolar lavage.The treatment efficacy and adverse reactions were observed, and the degree of lung infection and prognosis were evaluated by the clinical application of pulmonary infection score (CPIS) and acute physiology and chronic health Ⅱ (APACHE-Ⅱ) before and after the treatment.The treatment time or symptom improvement time was recorded, and the serum levels of inflammatory cytokines before and after the treatment were detected.Results: The effective rate of the observation group was 60.00%, which was higher than that of the control group (43.64%, P<0.05).CPIS and APACHE-Ⅱ scores in both groups decreased after the treatment, and those of the observation group were lower than those of the control group (P<0.05).The levels of procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) in both groups decreased after the treatment, and those of the observation group were lower than those of the control group (P<0.05).The time of mechanical ventilation, infection control window appearance and respiratory failure correction, pulmonary inflammation disappearance and antibiotics application of the observation group was shorter than that of the control group (P<0.05).The adverse reactions in the two groups showed no statistically significant differences(P>0.05).Conclusion: Xuebijing combined with bronchoalveolar lavage shows better clinical efficacy in the adjunctive therapy of severe pulmonary infection with improved prognosis, shorter treatment time, decreased levels of inflammatory factors and promising security.
