Ktrans of dynamic contrast enhanced MRI in evaluation of anti-angiogenic effects on nude mice with orthotopic transplantation tumor model of gastric cancer
10.13929/j.1003-3289.201610144
- VernacularTitle:DCE-MRI定量参数Ktrans值评估抗血管生成药物治疗裸鼠胃癌原位移植瘤的疗效
- Author:
Xuelian SHI
;
Gaofeng SHI
;
Xiaoling WANG
;
Qi WANG
;
Hui LIU
- Keywords:
Magnetic resonance imaging;
Stomach neoplasms;
Models,animal;
Angiogenesis inhibitors
- From:
Chinese Journal of Medical Imaging Technology
2017;33(6):843-847
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the feasibility of K value of dynamic contrast enhanced MRI (DCE-MRI) in evaluation of anti-angiogenic effects on nude mice with orthotopic transplantation tumor model of gastric cancer.Methods Nude mice with orthotopic transplantation tumor model of gastric cancer were randomly assigned to two groups:Treatment group (n =15),mice were given apatinib intragastrically for 18 days (100 mg/kg),and control group (n=15),mice were given ddH2O2 in the same manner.After 18 days,DCE-MRI was performed and K value was measured.Then the tumors were dissected from the adjacent tissues in order to detect the microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression levels.MVD and VEGF expression level were compared between treatment group and the control group.Results MVD (x2 =4.89,P＜0.05) and VEGF expression level (x2 =8.69,P＜0.01) of treatment group were much lower than those of control groups.The Kt value of treatment group was significantly lower than that of control groups ([0.63±0.05]/min vs [1.66±0.23]/min,t=17.05,P＜0.01).Conclusion The value of k in DCE-MRI can be utilized to assess the effects of apatinib on nude mice with orthotopic transplantation model of gastric cancer.
