Association between platelet distribution width and heart failure due to coronary heart disease
10.3969/j.issn.1009-0126.2017.06.004
- VernacularTitle:血小板分布宽度与冠心病心力衰竭相关性的临床研究
- Author:
Bin LI
;
Kun WANG
;
Gang ZHENG
- Keywords:
coronary disease;
heart failure;
blood platelets;
coronary angiography;
hemoglobins;
platelet aggregation inhibitors
- From:Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2017;19(6):569-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association between platelet distribution width (PDW) and other indexes in coronary heart disease (CHD) patients with heart failure (HF).Methods Five hundred and ninety-one CHD patients with HF were divided into control group with their NT-proBNP＜300 ng/L (n=228),mild HF group with their NT-proBNP=300-3000 ng/L (n=191),and severe HF group with their NT-proBNP＞3000 ng/L(n=172).Their blood and echocardiographic parameters were recorded.Results The PDW was significantly shorter in 3 groups after treatment than before treatment (0.129±0.031 vs 0.133±0.027,0.133±0.030 vs 0.141± 0.029,0.139±0.028 vs 0.148±0.029,P＜0.05,P＜0.01),and was significantly longer in mild HF group and severe HF group than in control group and in severe HF group than in mild HF group after tgreatment (P＜0.05,P＜0.01).Multivariate stepwise regression analysis showed that PDW was positively associated with NT-proBNP and LAD (P=0.001,P=0.000) and negatively associated with LVEF (P=0.003).Conclusion PDW increases with the severity of HF in CHD patients and can thus play an auxiliary role in assessing the severity of their HF.
