Research progress on VEGF and its related signaling pathway in ischemic brain injury and intervention of Traditional Chinese Medicine
10.7501/j.issn.1674-6376.2017.06.029
- VernacularTitle:VEGF信号通路在缺血性脑损伤中的作用及中药调节的研究进展
- Author:
Tianhong ZHAO
;
Shihan GENG
;
Simiao FAN
;
Yanjun ZHANG
- Keywords:
vascular endothelial growth factor (VEGF);
VEGF-related signaling pathway;
blood-brain barrier;
ischemic brain injury
- From:
Drug Evaluation Research
2017;40(6):874-879
- CountryChina
- Language:Chinese
-
Abstract:
The common complication of ischemic brain injury was ischemic brain edema,which was closely related to the function of the blood-brain barrier (BBB).In vitro studies,which have shown that vascular endothelial growth factor (VEGF) could bind to the receptor to activate a variety of cell signaling pathways,by inhibiting cell apoptosis,reduce oxidative stress and play a protective role in the brain.Fulong Antithrombotic Pill,Shenfu Injection,Naotaitong Granule and others traditional Chinese medicine can regulate the treatment of BBB injury by VEGF regulation.This article reviewde the study progress of VEGF and its related pathways in ischemic brain injury,and the treatment of BBB injury by Chinese medicine by interventional VEGF and its related pathways,which provide a theoretical basis for the clinical treatment of cerebral ischemic abnormalities and the development of new drugs.
