Relieving Cough and Reducing Sputum Effects and Safety of Total Alkaloid in Atalantia Buxifolia
- VernacularTitle:东风桔总生物碱止咳祛痰作用及安全性考察
- Author:
Rongrong DENG
;
Yongchang HUANG
;
Yongqin YIN
;
Pengfei LIN
;
Xionghui YANG
;
Zhibin SHEN
- Keywords:
Atalantia buxifolia;
Total alkaloid;
Relieving cough and reducing sputum;
Safety
- From:
China Pharmacist
2017;20(6):978-981
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the relieving cough and reducing sputum effects of total alkaloid in Atalantia buxifolia and evaluate the safety preliminarily.Methods: The relieving cough and reducing sputum effects of total alkaloid in Atalantia buxifolia were studied by the cough model caused by the irritation of ammonia water and the phenol red output of trachea in mice.The acute toxicity test and maximum tolerance test were carried out to evaluate the safety.Results: The total alkaloid in Atalantia buxifolia at low dose could obviously prolong cough incubation period and decrease cough times in mice, and that at high dose could significantly increase the secretion of phenol red in respiratory tract, and compared with those in the blank group, the differences were statistically significant (P<0.05).In the acute toxicity test, no death showed after the administration with maximum tolerance dosage, and the rate of weight growth had no difference between the blank group and the model group (P>0.05).Conclusion: The relieving cough and reducing sputum effects of total alkaloid in Atalantia buxifolia are notable in the cough model caused by the irritation of ammonia water and the phenol red output of trachea in mice.The maximum tolerable dose test shows the total alkaloid in Atalantia buxifolia is safe.
