Preparation and in vitro Evaluation of Self-microemulsifying Drug Delivery System of Adefovir Dipivoxil
- VernacularTitle:阿德福韦酯自微乳释药系统的制备和体外评价
- Author:
Xia TIAN
;
Ning WANG
;
Yunzhou FAN
;
Yuan SUN
;
Xiuxiu TIAN
;
Jiangsheng DING
- Keywords:
Adefovir dipivoxil;
Self-microemulsifying;
Pseudo-ternary phase diagram;
Orthogonal design
- From:
China Pharmacist
2017;20(6):997-1000
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare and in vitro evaluate the self-microemulsifying drug delivery system (SMEDDS) of adefovir dipivoxil (ADV).Methods: The optimized formula was screened by solubility, compatibility, ternary phase diagram and orthogonal design with the self-emulsifying time and particle size of microemulsion as the indices.The property of self-emulsification and the dissolution in vitro of ADV-SMEDDS were also determined.Results: The optimized SMEDDS was composed of Cremophor EL35 (37.5%), Transcutol HP (37.5%) and PECEOL (25%), and the drug loading was 3%.The ADV-SMEDDS formed stable microemulsion after the dilution by 50-fold amount of water in 24 s, the average particle size was (26.30±0.46) nm, the zeta potential was (-8.96±0.57) mV, and the dissolution was more than 85% in 5 min.Conclusion: The optimized formula of ADV-SMEDDS has significantly enhanced solubility and dissolution of adefovir dipivoxil in vitro.
