Formula Optimization of Ibuprofen Sustained-release Dropping Pills by Box-Behnken Response-surface Method
- VernacularTitle:Box-Behnken效应面法优化布洛芬缓释滴丸的处方
- Author:
Yanli SHEN
;
Hao CHEN
;
Hongxin SONG
;
Weixia DU
;
Yongyan JIA
- Keywords:
Ibuprofen;
Sustained-release dropping pills;
Box-Behnken response-surface method;
Solid dispersion
- From:
China Pharmacist
2017;20(6):1012-1016
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare ibuprofen sustained-release dropping pills, to evaluate the accumulative release percentage in vitro and to study the drug state in the base.Methods: With the drug content, mass ratio of water-soluble base to insoluble base and mass ratio of stearic acid to glyceryl monostearate as the investigation factors, and the comprehensive score of 2-hour and 10-hour cumulative dissolution rate as the evaluation index, a Box-Behnken response-surface method was used to screen the optimal formula of ibuprofen sustained-release dropping pills.The drug state in the matrix was examined by differential scanning calorimetry (DSC).Results: The optimal formula of ibuprofen sustained-release dropping pills was as follows: the drug content of 10%, water-soluble and insoluble matrix ratio of 4∶1, and stearic acid and glyceryl monostearate ratio of 3∶1.The maximum cumulative dissolution rate of ibuprofen sustained-release dropping pills was 78.85%.The DSC analysis showed that the drug crystallization peak disappeared in the sustained-release dropping pills, and formed a solid dispersion.Conclusion: The preparation has good sustained-release effect, and the preparation process is simple.
