Antiemetic Effect of Ethyl Acetate Extract with Ethanol Extraction of Galangal in Allotriophagic Kaolin-induced Model Rats
- VernacularTitle:高良姜醇提乙酸乙酯萃取物对异嗜高岭土模型大鼠的止呕作用
- Author:
Yang LIU
;
Dongqin SU
;
Ying ZHANG
- Keywords:
Galangal extract;
Antiemetic effect;
Substance P;
5-Hydroxytryptamine;
Dopamine
- From:
China Pharmacist
2017;20(6):1020-1022,1034
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antiemetic effect of the ethyl acetate extract with ethanol extraction of Galangal (hereinafter referred to as galangal extract) in allotriophagic Kaolin model rats.Methods: The rats were administered respectively with chemical drug cisplatin and apomorphine, and received the rotation stimulation as well.Three types of allotriophagic Kaolin models were established, and apomorphine, ondansetron and metoclopramide were used as the control drugs.The experimental rats were divided into 3 groups at low, medium and high dose of Galangal extract with prophylactic effect.The antiemetic effect was observed after the treatment.Results: Chemical drug cisplatin (3.0 mg·kg-1, intraperitoneal injection) and apomorphine (3.2 mg·kg-1,subcutaneous injection) and the rotation stimulation (centrifugal force of 3.4×g,60min) could induce allotriophagic vomiting in rats.The galangal extract at low (1 500 mg·kg-1), medium (4 500 mg·kg-1) and high (9 000 mg·kg-1) dose all fail to effectively inhibit the allotriophagic Kaolin behavior of rats caused by cisplatin, apomorphine and rotation(P>0.05).Conclusion: Galangal extract can not effectively inhibit the vomiting of allotriophagic Kaolin model rats.Probably, there is no correlation between the pharmacological effects of galangal extract and substance P, 5-hydroxytryptamine, dopamine as well as receptive zone of chemical vomiting inhibition.
