Serial Frozen Fecal Microbiota Transplantation in the Treatment of Chronic Intestinal Pseudo-obstruction: A Preliminary Study.
- Author:
Lili GU
1
;
Chao DING
;
Hongliang TIAN
;
Bo YANG
;
Xuelei ZHANG
;
Yue HUA
;
Yifan ZHU
;
Jianfeng GONG
;
Weiming ZHU
;
Jieshou LI
;
Ning LI
Author Information
- Publication Type:Original Article
- Keywords: Intestinal pseudo-obstruction; Fecal microbiota transplantation; Tolerance of enteral nutrition
- MeSH: Breath Tests; Enteral Nutrition; Fecal Microbiota Transplantation*; Humans; Hydrogen; Intestinal Obstruction; Intestinal Pseudo-Obstruction*; Lactulose; Pilot Projects; Prospective Studies
- From:Journal of Neurogastroenterology and Motility 2017;23(2):289-297
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Chronic intestinal pseudo-obstruction (CIPO) is a serious, life-threatening motility disorder that is often related to bacterial overgrowth. Fecal microbiota transplantation (FMT) results in restoration of the normal intestinal microbial community structure. We investigated the efficacy of FMT in the treatment of CIPO patients. METHODS: Nine patients (age 18–53 years) with CIPO were enrolled in this prospective, open-label study. Patients received FMT for 6 consecutive days through nasojejunal (NJ) tubes and were followed up for 8 weeks after treatment. We evaluated the rate of clinical improvement and remission, feeding tolerance of enteral nutrition, and CT imaging scores of intestinal obstructions. Lactulose hydrogen breath tests were performed before FMT and 8 weeks after FMT to evaluate for the presence small intestinal bacterial overgrowth (SIBO). RESULTS: FMT significantly alleviated bloating symptoms, and symptoms of pain were relieved 2 weeks after FMT. Enteral nutrition administered through a NJ tube after FMT was well-tolerated by 66.7% (6/9) of patients. CT scores of intestinal obstructions were significantly reduced after FMT (P = 0.014). SIBO was eliminated in 71.0% (5/7) of patients. CONCLUSIONS: This pilot study demonstrated the safety of using FMT. FMT may relieve symptoms in selected patients with CIPO. FMT may also improve patient tolerance of enteral nutrition delivered via a NJ tube.
