Study on the Protective Effect and Mechanism of JXHG Decoction on Alcohol Hepatic Injury in Mice
- VernacularTitle:姜蚬护肝汤对酒精性肝损伤小鼠模型的保护作用及机制研究
- Author:
Yuan ZHOU
;
Bing LIAO
;
Xurui WANG
;
Qingyang XIONG
;
Zhu DAI
- Keywords:
JXHG Decoction;
alcohol hepatic injury;
peroxidation damage;
apoptosis;
mice
- From:
China Pharmacist
2017;20(6):1042-1045
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the protective effect and mechanism of JXHG Decoction on alcoholic liver injury.Methods: Each group of mice were fed for 30 days.Then 50% alcohol used to establish hepatic injury in mice by intragastric administration.16 hours later, the levels of TNF-α, AST, ALT in serum and MDA, GSH, TG, Caspase-3, Caspase-8 in liver were measured accordingly.Results: JXHG Decoction could reduce the levels of TNF-α, AST, ALT, MDA, TG, Caspase-3, Caspase-8, NF-κB and increase GSH, while alleviated tissue necrosis and aelipose degeration of hepar.Conclusion: JXHG Decoction has favorable anti-effects on alcoholic liver injury.Its possible mechanisms are reducing the inflammatory reaction by depressing the expression of TNF-alpha and NF-kappa B in liver cells, and alleviating the hepatic cell apoptosis induced by Caspase-8 and Caspase-3.
