Efficacy of Telmisartan Combined with Amiodarone in the Patients with Hypertension Complicated with Paroxysmal Atrial Fibrillation and Influence on the Levels of Serum BNP, MMP-2 and CTGF
- VernacularTitle:替米沙坦联合胺碘酮治疗高血压伴阵发性心房颤动患者疗效及对血清BNP、MMP-2及CTGF水平的影响
- Author:
Song LIN
- Keywords:
Hypertension;
Atrial fibrillation;
Telmisartan;
Amiodarone;
Brain natriuretic peptide;
Matrix Metalloproteinase-2;
Connective tissue growth factor
- From:
China Pharmacist
2017;20(6):1055-1058
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of telmisartan combined with amiodarone on the levels of serum brain natriuretic peptide (BNP), matrix metalloproteinase-2 (MMP-2) and connective tissue growth factor (CTGF) in the patients with hypertension complicated with paroxysmal atrial fibrillation.Methods: A total of 90 hypertensive patients with paroxysmal atrial fibrillation were randomly divided into amiodarone+ telmisartan group and amiodarone group.The 45 patients in amiodarone group were treated with amiodarone hydrochloride and the 45 patients in amiodarone+telmisartan group were treated with telmisartan combined with amiodarone.After 12-month treatment, the clinical effect, changes of blood pressure, heart rate, left atrial volume, recurrence frequency and duration time of atrial fibrillation were compared between the groups, and the levels of serum BNP, MMP-2 and CTGF before and after the treatment were detected.Results: The total effective rate of amiodarone+telmisartan group was 95.6%, which was significantly higher than that of amiodarone group (75.6%, P<0.05).The blood pressure, recurrence frequency and duration time of atrial fibrillation were significantly improved after the treatment in the two groups (P<0.05).The blood pressure, left atrial volume and situation of atrial fibrillation in amiodarone+telmisartan group were better than those in amiodarone group after the treatment (P<0.05).The levels of serum MMP-2 and CTGF were significantly reduced in the two groups after the treatment, and the levels of BNP, MMP-2 and CTGF in amiodarone+telmisartan group were significantly lower than those in amiodarone group (P<0.05).The incidence of adverse reaction was not significantly different in the two groups (P>0.05).Conclusion: Telmisartan combined with amiodarone in the treatment of hypertension complicated with paroxysmal atrial fibrillation shows promising curative effect, which can inhibit the left atrial expansion, decrease the frequency and duration time of atrial fibrillation and reduce the levels of serum BNP, MMP-2 and CTGF.
