Standardized methods for bone marrow micronucleus test in rodents and historical data collection
10.7501/j.issn.1674-6376.2017.05.010
- VernacularTitle:啮齿类动物骨髓微核试验规范化方法介绍及背景数据采集
- Author:
Hairuo WEN
;
Jie SONG
;
Zhihui MAO
;
Jian GUO
;
Xin WANG
;
Yanping HU
- Keywords:
bone marrow micronucleus test;
background data;
genetic toxicity;
chromosome breakage;
cyclophosphamide
- From:
Drug Evaluation Research
2017;40(5):638-641,647
- CountryChina
- Language:Chinese
-
Abstract:
In vivo Mammalian Bone Marrow Micronucleus Test is included in the standard battery genotoxicity testing,with great application prospects in medicine,public health,food and drug safety evaluation fields.Establishing standardized experimental methods and conditions in GLP condition and accumulating a certain range of background data could effectively ensure the reliability of the test system,and also provide strong basis to support the experimental data.We herein summarized the background data of mouse and rat bone marrow micronucleus tests performed from 2007 to 2015,to expound the standardized data collection method for rodent animal bone marrow micronucleus test.
