Effect of Reduning Injection combined with spleen aminopeptide oral solution on children with hand-foot-and-mouth disease and its regulative effect on myocardial enzyme and inflammatory level
10.7501/j.issn.1674-6376.2017.05.017
- VernacularTitle:热毒宁注射液联合脾氨肽口服液治疗小儿手足口病的疗效分析及对心肌酶、免疫水平的调节作用
- Author:
Xiaoxiang LI
;
Li ZHOU
- Keywords:
Reduning Injection;
spleen aminopeptide oral solution;
hand-foot-and-mouth disease;
immunity;
myocardial enzyme
- From:
Drug Evaluation Research
2017;40(5):675-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Reduning Injection (RI) combined with spleen aminopeptide oral solution on children with hand-foot-and-mouth disease and its regulative effect on myocardial enzyme and inflammatory level.Methods Totally 184 cases treated in Children's Hospital of Kaifeng City from September,2014 to September,2016 were randomly divided into observation group and control group with each group of 92 cases.Control group was given conventional therapy,on the basis of which,observation group was given RI combined with spleen aminopeptide oral solution.Clinical effect and levels of inflammatory cytokine and myocardial enzyme were compared between the two groups.Results The total effective rate in observation group was 93.48％,which was significantly higher than that in control group (80.43％) (P ＜ 0.05).After therapy,the levels ofhs-cTnT,CK-MB,CK,TNF-α,IL-6,CRP,CD3+,CD4+,CD8+,IgA,IgM,and IgG in observation group showed no statistical difference compared with healthy group.Index mentioned above of control group were significantly improved,however there were still statistical difference compared with healthy group (P ＜ 0.05).Conclusion RI combined with spleen aminopeptide oral solution could effectively decrease the levels of inflammatory cytokine as well as myocardial enzyme,which deserves clinical expansion.
