Efficacy and safety of amisulpride and clozapine in schizophrenia patients with predominantly negative symptoms
10.7501/j.issn.1674-6376.2017.05.021
- VernacularTitle:氨磺必利与氯氮平治疗阴性症状为主的精神分裂症的疗效及安全性比较
- Author:
Jing LI
;
Jie YUAN
;
Xueli ZHOU
;
Na ZHAO
;
Yufei ZHANG
- Keywords:
schizophrenia;
negativesymptoms;
amisulpride;
clozapine;
qbnormal electrocardiogram
- From:
Drug Evaluation Research
2017;40(5):691-695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of amisulpride and clozapine in schizophrenia patients with predominantly negative symptoms.Methods Totally 166 cases of schizophrenia patients with predominantly negative symptoms from May 2013 to May 2016 in The Sixth People's Hospital of Hebei were divided into observation group and control group,83 cases in each group.Patients in the observation group were treated with amisulpride,and control group were treated with clozapine.The clinical effect,SANS scores,and occurring rate of abnormal electrocardiogram were compared.Results The clinical effect,emotional insipid (blunting),and attention dysfunction scores from SANS of observation group were significantly better than those of control group on week 4,8,and 12,respectively (P ＜ 0.05);The occurring rate of abnormal electrocardiogram in observation group was significantly lower than that of control group on week 12 (P ＜ 0.05).Conclusion Compared with clozapine,amisulprid has better efficacy and safety in schizophrenia patients with predominantly negative symptoms,and can effectively improve of symptom of insipid (blunting) and attention dysfunction.
