Summary of research methods for drug intestinal absorption
10.7501/j.issn.1674-6376.2017.05.024
- VernacularTitle:药物肠道吸收研究方法概述
- Author:
Yifan LUO
;
Lixiang REN
;
Xiaohong LI
;
Yaoting SUN
;
Mingyan JIANG
- Keywords:
intestinal absorption;
drug evaluation;
in situ;
intestinal perfusion;
recirculating perfusion;
single-pass perfusion
- From:
Drug Evaluation Research
2017;40(5):706-710
- CountryChina
- Language:Chinese
-
Abstract:
At present,the study of intestinal absorption of oral drugs mainly includes in vitro,in vivo and in situ methods.In view of the advantages of in situ intestinal perfusion such as simple operation,mature technology,controllable,ensure the neuroendocrine regulation and blood supply,and so on,which could better reflect the true situation of drug absorption.In this study,the research methods and characteristics of intestinal absorption of oral drugs were systematically introduced.The recirculating perfusion method and single-pass perfusion method were compared,and several volume correction methods were also introduced.In order to ensure the operability and accuracy of experimental results,proper experiment method of intestinal absorption will be adopt according to the factors such as drug characters,experiment requirements,experimental conditions,and so on.The article provides a scientific basis for the development of pharmaceutical dosage and clinical rational drug use.
