Research progress on vascular pharmacologic effect of salidroside
10.7501/j.issn.1674-6376.2017.05.026
- VernacularTitle:红景天苷的血管药理作用研究进展
- Author:
Mingfa ZHANG
;
Yaqin SHEN
- Keywords:
salidroside;
tyrosol;
blood vessel;
pharmacologic effect;
pulmonary hypertension;
atherosclerosis
- From:
Drug Evaluation Research
2017;40(5):717-724
- CountryChina
- Language:Chinese
-
Abstract:
Salidroside antagonizes hypoxia,H2O2,hyper-glucose,homocysteine,smoking,orweightlessness-induced endothelial cell injury,and antagonizes the proliferation of vascular smooth muscle cells and vascular adventitial fibroblasts induced by hypoxia,hyper-glucose,noradrenaline,platelet-derived growth factor,or angiotensin Ⅱ,thus produces vascular protection and improves vascular function.Salidroside plays a dual role of vasoconstriction and vasodilation in regulating resistant blood vessel.The vasodilatory effect of salidroside is endothelium-dependent and endothelium-independent.Salidroside antagonizes vascular contraction and injury induced by KCl,CaCl2,noradrenaline,phenylephrine,homocysteine,hyper-glucose,plateau hypoxia,H2O2,and chlorine.Salidroside relieves cerebral vasospasm induced by subarachnoid hemorrhage,and pulmonary hypertension and pulmonary arterial remodeling induced by hypoxia or monocrotaline in rat,attenuates several experimental atherosclerosis,and enhances plaque stability.
