Effect of sevoflurane preconditioning on autophagy in operated lung tissues of patients undergoing one-lung ventilation
10.3760/cma.j.issn.0254-1416.2017.04.009
- VernacularTitle:七氟醚预处理对单肺通气患者术侧肺组织自噬的影响
- Author:
Yangyang HAN
;
Hao ZHU
;
Kai ZHANG
;
Yan WANG
;
Changshun HUANG
;
Xiangming FANG
- Keywords:
Anesthetics,inhalation;
Ischemic preconditioning;
Autophagy;
Respiration,artificial;
Respiratory distress syndrome,adult
- From:
Chinese Journal of Anesthesiology
2017;37(4):417-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of sevoflurane preconditioning on autophagy in the operated lung tissues of the patients undergoing one-lung ventilation.Methods Forty patients of both sexes,with American Society of Anesthesiologists physical status Ⅰ-Ⅲ,aged 30-80 yr,weighing 45-84 kg,scheduled for elective radical operation for lung cancer performed via video-assisted thoracoscope under general anesthesia,were divided into control group (C group) and sevoflurane preconditioning group (SP group),with 20 patients in each group.In SP group,sevoflurane was inhaled for 30 min with the final concentration of 2.0％,followed by washout.The normal lung tissues (the distance from the edge of the lump＞2 cm) around the lump were obtained for detection of the expression of microtubule-associated protein 1 light chain 3 Ⅱ by Western blot.Results Compared with C group,the expression of microtubule-associated protein 1 light chain 3 Ⅱ in lung tissues was significantly up-regulated in SP group (P＜0.05).Conclusion Sevoflurane preconditioning can enhance autophagy in the operated lung tissues of the patients undergoing one-lung ventilation,which may be related to the lung protective effect.
