Effect of oxycodone combined with incision infiltration with ropivacaine on postoperative outcomes in patients undergoing laparoscopic cholecystectomy
10.3760/cma.j.issn.0254-1416.2017.04.025
- VernacularTitle:羟考酮联合罗哌卡因切口浸润对腹腔镜胆囊切除病人术后转归的影响
- Author:
Liang WANG
;
Xiaoqiong XIA
;
Shujiang XIA
;
Yan WANG
;
Jun LI
;
Dong AN
- Keywords:
Oxycodone;
Anesthesia,local;
Cholecystectomy,laparoscopic
- From:
Chinese Journal of Anesthesiology
2017;37(4):475-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of oxycodone combined with incision infiltration with ropivacaine on postoperative outcomes in the patients undergoing laparoscopic cholecystectomy.Methods Eighty American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients of both sexes,aged 33-64 yr,weighing 45-88 kg,scheduled for elective laparoscopic cholecystectomy under general anesthesia,were divided into 2 groups (n=40 each) using a random number table:patient-controlled intravenous analgesia group (group P) and oxycodone combined with incision infiltration group (group O).In group P,fentanyl 1-2 μg/kg was intravenously infused after cholecystectomy,and patient-controlled intravenous analgesia was performed with sufentanil at the end of surgery.In group O,oxycodone 0.05-0.10 mg/kg was intravenously injected after cholecystectomy,incision infiltration was performed with 0.5％ ropivacaine before suturing,and visual analog scale score was maintained ≤ 3.The emergence time,time to first flatus,time to liquid diet,first ambulation time,length of hospital stay after operation and adverse reactions were recorded.Results Compared with group P,the time to first flatus,time to liquid diet,first ambulation time and length of hospital stay after operation were significantly shortened,the incidence of urinary retention and nausea and vomiting was decreased (P＜0.05),and no significant change was found in the emergence time in group O (P＞0.05).Conclusion Combination of oxycodone and incision infiltration with ropivacaine can promote postoperative outcomes in the patients undergoing laparoscopic cholecystectomy.
