Toxicological pathology in preclinical drug safety evaluation
10.7501/j.issn.1674-6376.2017.04.004
- VernacularTitle:临床前药物安全性评价中的毒性病理学
- Author:
Zhi LIN
;
Jianjun LV
;
Guitao HUO
;
Di ZHANG
;
Yanwei YANG
;
Shuo ZHANG
;
Xue WANG
;
Bo LI
;
Zhe QU
- Keywords:
toxicological pathology;
drug toxicity;
drug safety evaluation;
standardized management;
pathologic technique
- From:
Drug Evaluation Research
2017;40(4):450-454
- CountryChina
- Language:Chinese
-
Abstract:
Toxicological pathology is a morphological elucidatet ion of tissue damage caused by drug toxicity,including damage type,location,severity grade and prognosis.It provides objective and accurate data to support preclinical drug safety evaluation.Therefore,toxicological pathology plays an important role in drug safety evaluation,and the pathologic data or conclusion often determines the termination or continuation in many drug development projects.In this paper,the characteristic of toxicological pathology,standardized management,the development of new techniques including in situ hybridization,laser scanning cytometry and laser capture microdissection,and related problems in pathology are discussed briefly.
