Inhibition of the crude extract of Eriobotryae Folium collected from different districts towards phosphodiesterase-4
10.7501/j.issn.1674-6376.2017.06.007
- VernacularTitle:不同产地枇杷叶粗提物抑制磷酸二酯酶4活性研究
- Author:
Bingxin TAN
;
Yiyou HUANG
;
Guangtian PENG
;
Haibin LUO
;
Si YU
;
Xiaolei GUO
;
Xixin HE
- Keywords:
Eriobotryae Folium;
phosphodiesterase 4 (pde4);
inhibition
- From:
Drug Evaluation Research
2017;40(6):769-772
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibition of Eriobotryae Folium from twenty different districts towards phosphodiesterase 4(PDF4) in vitro.Methods The Eriobotryae Folium were extracted with 95% ethanol reflux and the inhibition rates against PDE4D2 were carried out by liquid scintillation counting method.Results All the samples exhibited inhibitory activities towards PDE4 at 5 mg/L.Among them,nine samples were of the inhibition rate less than 80%,eleven samples were of more than 80% inhibition and eight samples were of more than 90% inhibition.Conclusion The Eriobotryae Folium shows significantly different inhibitory activities towards PED4.