Research advances on pharmacologic effects of Ligustri Lucidi Fructus and its active constituents in skeletal muscle
10.7501/j.issn.1674-6376.2017.04.027
- VernacularTitle:女贞子及其活性成分的骨骼肌药理作用研究进展
- Author:
Mingfa ZHANG
;
Jianhua GAO
;
Yaqin SHEN
- Keywords:
Ligustri Lucidi Fructus;
ursolic acid;
salidroside;
muscle growing;
muscle atrophy;
muscle fatigue
- From:
Drug Evaluation Research
2017;40(4):571-576
- CountryChina
- Language:Chinese
-
Abstract:
Ligustri Lucidi Fructus and its active constituents,ursolic acid and salidroside,have insulin-like effect to produce positive action on skeletal muscle:,It can improve the utilization of carbohydrate and lipid in muscle,increase synthesis of muscular glycogen and protein,muscular weigh,size of fast-and slow-muscle fibers,and accelerate transformation fast-muscle fiber toward slow-muscle fiber.Ursolic acid stimulates muscle satellite cells proliferation,myogenic differentiation of myoblasts,enhances neomyogenesis in skeletal muscle,and promotes skeletal muscle rejuvenation.In addition,Ligustri Lucidi Fructus and its active constituents down-regulating repression of atrogin-1 and muscle ring-finger protein-1 (MuRF-1),and anti-oxidation and anti-inflammation,it may protect and treat for muscle atrophy and fatigue-induced muscle injury.
