Clinical control study on efficacy of aspirin and rivaroxaban on prevention of deep vein thrombosis after total knee replacement
10.7501/j.issn.1674-6376.2017.06.019
- VernacularTitle:阿司匹林与利伐沙班预防全膝关节置换后下肢深静脉血栓的临床对照研究
- Author:
Ming HAO
;
Wenya LI
- Keywords:
aspirin;
rivaroxaban;
total knee repalcement;
deep vein thrombosis
- From:
Drug Evaluation Research
2017;40(6):824-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of aspirin and rivaroxaban on prevention of deep vein thrombosis after total knee repalcement.Methods Patients (200 cases) who were given total knee replacement were selected,and the patients in aspirin group (98 cases) were administered with asprin after 12 h treatment,and the patients in rivaroxaban group (102 cases) were administered with rivaroxaban after 12 h treatment.The efficacy of aspirin and rivaroxaban to prevent deep vein thrombosis after total knee repalcement was evaluated by blood coagulation indexes,D-dimer level,and complication during perioperative period.Results Before surgery,there was no statistically significant difference on coagulation indexes between two groups.After 3 d of operation,there was no statistically significant difference in Plt,APTT,and PT between two groups.The FIB level of aspirin group was improved significantly and higher than that of rivaroxaban group (P ＜ 0.05).While the FIB level of rivaroxaban group was close to the normal level.Before operation,there was no statistically significant difference in D-dimer between two groups.After 1,3,and 7 d of operation,the D-dimer levels in two groups were increased.But the D-dimer levels of 3 and 7 d after operation began to decline.After 1,3,and 7 d of operation,the D-dimer ofrivaroxaban group was lower than that of aspirin group (P ＜ 0.05).During perioperative period,there was no statistically significant difference on DVT between two groups.Conclusion Rivaroxaban could prevent the formation of DVT effectively and reduce the D-dimer with good anticoagulation and high safety.It is worthy of clinical application.
