Establishment and assessment of a rat model of functional dyspepsia with spleen deficiency
10.3969/j.issn.1005-4847.2017.03.014
- VernacularTitle:功能性消化不良脾虚证大鼠模型的建立及评价
- Author:
Chengquan LIU
;
Qing DENG
;
Zhichao TAN
;
Hua YANG
;
Dejian JIANG
;
Guirong ZENG
- Keywords:
Functional dyspepsia;
Spleen deficiency;
Iodoacetamide;
Rats
- From:
Acta Laboratorium Animalis Scientia Sinica
2017;25(3):311-315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish animal models of functional dyspepsia with spleen deficiency and to compare the efficacy of different methods.Methods Rat models were established by iodoacetamide(IA)-treatment or combined with swimming.Appearance,body weight,food intake of the rats were observed,and serum motilin,cholecystokinin,lactate,gastrin content and urinary D-xylose excretion rates were detected to confirm whether the model of functional dyspepsia with spleen deficiency was established.Results The IA-treated rats had less food intake and a slower body weight gain.The IA-treated combined with swimming rats presented spleen-hypofunction symptoms,such as emaciation,hair dry and loose stools,their urinary D-xylose excretion rate,serum motilin,gastrin content were decreased,and serum cholecystokinin and lactate contents were increased significantly (P<0.05 for all).Conclusions All the three methods used in this study can result in symptoms of functional dyspepsia with spleen deficiency.However,IA-treatment combined with swimming models appear more close to spleen deficiency-like presentation,and the best model is the IA-treated combined with platform standing.
