Research progress on chemical constituents in hydrolyzed products of gypenosides and their pharmacological activities
10.7501/j.issn.1674-6376.2017.05.025
- VernacularTitle:绞股蓝皂苷水解产物化学成分和药理作用研究进展
- Author:
Lin SHI
;
Zhicheng WANG
;
Shengming SHI
;
Dehong TAN
- Keywords:
Gynostemma pentaphyllum (Thunb.) Makion;
gypenosides;
hydrolyzed products;
triterpenoid;
dammarane
- From:
Drug Evaluation Research
2017;40(5):711-716
- CountryChina
- Language:Chinese
-
Abstract:
The biologically active constituents in Gynostemma pentaphyllum are dammarane-type glycosides,called gypenosides.They are believed to be the highest contents of this herb,easy to obtain,and mainly active in anti-tumor,controlling the blood glucose,lipid-lowering,cardiovascular protection,etc.The saponins may change into sub-glucoside after hydrolysis,for the intemal acetal glucoside structure is vulnerable to acid,alkali,and enzyme degradation.Through searching the literatures in recent years,this paper summarized the chemical constituents in the hydrolyzed products of gypenosides,for providing references to discover novel and more active lead compounds.
