Effects of Uygur Medicine Branchlets roses extracts on blood glucose and glucose tolerance in diabetes mice induced by alloxan
10.7501/j.issn.1674-6376.2017.04.010
- VernacularTitle:维药小枝玫瑰提取物对四氧嘧啶糖尿病小鼠血糖及糖耐量的影响
- Author:
Wei LAN
;
Ying WANG
;
Yuwei HAO
;
Jingyi LIU
;
Dongqing AN
- Keywords:
Branchlets Rosa rugosa Thunb.;
alloxan;
diabetes mice;
hypoglycemic;
glucose tolerance
- From:
Drug Evaluation Research
2017;40(4):492-495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of extract from Branchlets roses on blood glucose and glucose tolerance in diabetes mice induced by alloxan.Methods Diabetes animal model was established by alloxan.Dividing the model mice into eight groups:model group,water extract high,middle,and low dose (3.70,1.85,and 0.93 g/kg) group,and ethanol extract high,middle,and low dose (2.75,1.37,and 0.70 g/kg) group,and metformin (positive drug,200 mg/kg) group,and normal mice were taken as control group.Drug was ig administered to mice 3 d after molding once daily.Blood glucose test paper was used to determine fasting blood glucose 0,10,20,and 28 d after modeling,and the glucose tolerance test was performed 30 d after modeling.Results The extract of Branchlets roses from all the groups could decrease the blood glucose and improve the glucose tolerance,and showed a certain dose-effect relationship.In all the extracts,the alcohol extract had the best effect,but the effect was not as good as the positive control drug metformin hydrochloride group.Conclusion The extract of Branchlets roses can reduce the blood sugar content of diabetic mice,and improve the glucose tolerance.
