Effect of dl-3n-butylphthalide on NT-proBNP levels and inflammatory cytokines of patients with acute cerebral infarction
10.7501/j.issn.1674-6376.2017.04.014
- VernacularTitle:丁苯酞对急性脑梗死患者NT-proBNP水平和血清炎症因子的影响
- Author:
Guangrong FU
;
Genyu LI
- Keywords:
acute cerebral infarction;
D1-3n-butylphthalide;
NT-proBNP;
inflammatory cytokines;
hs-CRP;
IL-6;
TNF-α
- From:
Drug Evaluation Research
2017;40(4):513-516
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of dl-3n-butylphthalide and its effect on NT-proBNP levels and inflammatory cytokines of patients with acute cerebral infarction.Methods Total 118 patients with acute cerebral infarction in Hengshui Fifth People's Hospital were randomly divided into control group and observation group.Sixty patients in control group were treated with conventional medication,and 58 patients in observation group were treated with dl-3n-butylphthalide injection based on conventional medication.The NT-proBNP levels,score of neurological deficits (NIHSS),inflammatory cytokines including hypersensitive C-reactive protein (hs-CRP),interleukin-6 (IL-6),and tumor necrosis factor-cα (TNF-α) before and after 7 and 14 d of treatment,and adverse reaction were observed and analyzed.Results Before treatment,differences in the NT-proBNP levels,NIHSS score,hs-CRP,IL-6,and TNF-α between two groups were not obvious.After 7 and 14 d of treatment,NT-proBNP levels in observation group were significantly lower than those in control group (P ＜ 0.05).And after treatment for 14 d,NIHSS score in observation group were conspicuously lower than those in control group (P ＜ 0.05).Additionally,the levels of hs-CRP,IL-6,and TNF-α in observation group were markedly lower than those in control group (P ＜ 0.05).Conclusion D1-3n-butylphthalide injection has a good ability in inhibiting NT-proBNP levels and inflammatory cytokines,and improves the neurological function of patients with acute cerebral infarction.
