Effect of different doses of ambroxol on efficacy and lung function of elderly patients with chronic obstructive pulmonary disease
10.7501/j.issn.1674-6376.2017.04.015
- VernacularTitle:不同剂量氨溴索对老年慢性阻塞性肺疾病患者的疗效及肺功能的影响
- Author:
Lu BAI
;
Lihong LI
;
Nan TAN
- Keywords:
Ambroxol;
COPD;
inflammation;
pulmonary ventilation
- From:
Drug Evaluation Research
2017;40(4):517-520
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of different doses of ambroxol on efficacy and lung function of elderly patients with chronic obstructive pulmonary disease.Methods 200 patients with COPD were selected.They were divided into two groups randomly.The high dose group (102 cases) were given anmbroxol hydrochloride in high doses.The low dose group (98 cases) were given anmbroxol hydrochloride in low doses.The effect of different doses of ambroxol on efficacy and lung function of elderly patients with chronic obstructive pulmonary disease was evaluated by the efficacy,TNF-α,CRP,pulmonary function indexes and adverse reaction during treatment.Results The effective rate was 89.2％ in the high dose group and 75.5％ in the low dose group.The effective rate of high dose group was higher than that of the low dose group (P ＜ 0.05).Before treatment,there were no statistical significance on CRP and TNF-α between two groups.After treatment,the CRP and TNF-α were decreased in two groups and lower in the high dose group (P ＜ 0.05).Before treatment,there were no statistical significance on FVC,FEV1 and FEV1/FVC％ between two groups.After treatment,FVC,FEV1 and FEV1/FVC were increased and higher in the high dose group (P ＜ 0.05).During treatment,there were no statistical significance on adverse reaction between two groups.Conclusion High dose of ambroxol was effective and safe for COPD.It could reduce inflammation and improve pulmonary ventilation with clinical use.
