Meta-analysis on Chitosan in repair clinical surgery wounds healing
10.7501/j.issn.1674-6376.2017.04.024
- VernacularTitle:壳聚糖对临床手术创面修复的Meta分析
- Author:
Jing ZHANG
;
Xun ZHANG
;
Yu LIN
;
Weichen WANG
- Keywords:
chitosan;
surgery;
wound healing;
Meta-analysis
- From:
Drug Evaluation Research
2017;40(4):553-559
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of chitosan in the repair of clinical surgery wounds.Methods The databases of Cochrane Controlled Trials Register (CCTR),Embase database,Medline database,PubMed database,CNKI database,WanFang database,VIP database and Chinese Biomedical Journal Library (CMCC) were retrieved with computer for collecting randomized controlled trials (RCT) about the repair clinical surgery wounds healing.Meta-analysis on all the data are carried out by RevMan 5.0 software.Results There were totally 16 trials and 3414 patients included.The results showed that the wound healing time ofchitosan was significantly shorter than that of the control group [WMD =-0.64,95％CI (-0.69～-0.59),P ＜ 0.000 01],and chitosan can better promote wound healing [RR =1.03,95％CI (1.01～1.04),P =0.0002].In experimental group,postoperativepain were reliever [WMD =-3.49,95％CI (-5.07～-1.91),P ＜ 0.0001],and postoperative infection were reduced [RR =0.49,95％CI (0.33～0.71),P =0.0002].Conclusion The existing evidences indicate that chitosan can shorten postoperative wound healing time,promote wound healing,relieve pain,and reduce infection.However,the study is limited by the quality of included literature,more clinical trials should be done to confirm the effective and safety.
