Advances in mechanism of action of naringin on diabetes mellitus and its complications
10.7501/j.issn.1674-6376.2017.04.025
- VernacularTitle:柚皮苷对糖尿病及其并发症作用机制的研究进展
- Author:
Nana MENG
;
Lixue BAI
;
Xinxin LI
;
Yijie WEN
;
Xiudong JIN
;
Yufei ZHANG
- Keywords:
naringin;
diabetes mellitus;
diabetic cardiomyopathy;
diabetic nephropathy;
diabetic retinopathy;
diabetic neuropathy
- From:
Drug Evaluation Research
2017;40(4):560-565
- CountryChina
- Language:Chinese
-
Abstract:
Naringin is mainly present in Rutaceae Citrus Pomelo,grapefruit,lime,and its variants of the peel and fruit,which belongs to dihydrogen flavonoids.Studies have shown that naringin has anti-type 1 and type 2 diabetes pharmacological effects,the mechanism of action by inhibiting diabetes-related oxidative stress injury,inflammation,abnormal metabolism of glucose,and other aspects,while a certain degree of delay in diabetes complications (including diabetic cardiomyopathy,diabetic nephropathy,diabetic retinopathy,and diabetic neuropathy).The mechanism of naringin on the mechanism of diabetes mellitus and its complications was studied in order to provide the basis for the development of antidiabetic drug.
