Gelatin sponge particlesversus chitosan/alpha, beta-glycerophosphate gel microspheres in hemoptysis of pulmonary tuberculosis
10.3969/j.issn.2095-4344.2017.18.015
- VernacularTitle:明胶海绵颗粒和壳聚糖α,β-甘油磷酸凝胶微球在肺结核咯血应用中的对比
- Author:
Ping JI
;
Zhe CHEN
;
Xiaochen SUN
;
Long YUAN
- Keywords:
Tuberculosis;
Pulmonary;
Gelatin Sponge;
Absorbable;
Chitosan;
Tissue Engineering
- From:
Chinese Journal of Tissue Engineering Research
2017;21(18):2876-2880
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:It is reported that gelatin sponge particles and chitosan/α, β-glycerophosphate gel microspheres have high application prospects in the treatment of hemoptysis of pulmonary tuberculosis.METHODS: Forty SPF Kunming mice were selected to make animal models of pulmonary tuberculosis hemoptysis using aerosolized inhalation device and randomly divided into two groups undergoing embolization for hemostasis using gelatin sponge particles and chitosan/α, β-glycerophosphate gel microspheres, respectively. Body mass changes, hemostasis time, effective rate of hemostasis, related indexes of myocardium and pathological changes of pulmonary tuberculosis were observed at 15 and 30 days after treatment.RESULTS AND CONCLUSION:(1) Mice in the chitosan/α, β-glycerophosphate gel microspheres group had higher body mass than those in the gelatin sponge group at 15 days after treatment (P < 0.05). (2) Compared with the gelatin sponge group, the hemostatic efficiency was higher and the time of hemostasis was shorter in the chitosan/α, β-glycerophosphate gel microspheres group (P< 0.05). (3) There were no significant differences in the levels of BNP precursor, creatine kinase isoenzyme and creatine kinase between the two groups (P > 0.05). (4) The lymphocyte infiltration and necrotic lesions were found around the microspheres, necrotic lesions were found, and there were a lot of active cells on the microspheres. There were a few lymphocytes in the gelatin sponge group. These results show that that the chitosan/α, β-glycerophosphate gel microspheres have better hemostatic effects in comparison with gelatin sponge particles in a mouse model of pulmonary tuberculosis.
