Correlation between ApoE gene polymorphisms and chronic cardiovascular disease and blood lipid levels of patients
10.3969/j.issn.1673-4130.2017.12.006
- VernacularTitle:ApoE基因多态性与慢性心血管疾病及患者血脂水平的相关性研究
- Author:
Aifen LIANG
;
Shaojian HE
;
Xianli HUA
;
Yali LEI
;
Hong SUI
;
Shuxian YU
- Keywords:
apolipoprotein E;
genetic polymorphism;
chronic cardiovascular disease;
lipid
- From:
International Journal of Laboratory Medicine
2017;38(12):1601-1602,1605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between apolipoprotein E(ApoE) gene polymorphisms and the incidence rate of chronic cardiovascular disease as well as the blood lipid levels of patients.Methods ApoE gene polymorphism and lipid levels were measured by suing gene chip analysis system and biochemical analyze in 1 414 cases of chronic cardiovascular disease patients(experimental groups) and 374 cases of healthy subjects(control group).Results Compared with control group,E3/4 genotype frequency was increased in experimental group,while E2/E3 genotype frequency decreased(P<0.05).Compared with control group,the levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C) were obviously increased and the level of HDL-C was decreased in experimental group(P<0.05).Compared with patients with E2/E3 genotype,the level of HDL-C in patients with E3/E4 genotype was decreased and the levels of TC,LDL-C were increased significantly(P<0.05).Proportions of different ApoE genotypes in patients with cerebral infarction,cerebral hemorrhage,hypertension,coronary heart disease,type-2 diabete and fatty liver were different.Compared with the E2/E3 genotype,the proportion of the E3/E4 genotype in patients with cerebral infarction,cerebral hemorrhage,hypertension,coronary heart disease,type-2 diabete and fatty liver were increased(P<0.05).Conclusion ApoE gene polymorphism might be important cause of the individual difference of lipid levels and a risk factor for the occurrence and development of chronic cardiovascular diseases.
