Comparison of the effects of metformin and insulin in gestational diabetes mellitus patients and the influence on neonatal
10.3969/j.issn.1673-4130.2017.12.004
- VernacularTitle:二甲双胍和胰岛素在妊娠糖尿病患者中的疗效对比观察及对新生儿的影响研究
- Author:
Xiaoyue YANG
;
Qunfeng YANG
;
Jiejun WAN
- Keywords:
metformin;
insulin;
gestational diabetes mellitus;
therapeutic effect;
neonatal
- From:
International Journal of Laboratory Medicine
2017;38(12):1594-1596
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of metformin and insulin in gestational diabetes mellitus(DM) patients and their effects on neonates.Methods From August 2012 to October 2016,60 patients with gestational diabetes mellitus were divided into control group(n=30) and observation group(n=30) by random number method.The control group was treated with insulin and the observation group was treated with metformin on the basis of the control group.The clinical effect and the effect on neonatal were compared between the two groups.Results The level of glycosylated hemoglobin in the observation group was higher than that in the control group(P<0.05).In the observation group,the levels of fasting plasma glucose,postprandial blood glucose 2 hours after meals and 4 hours postprandial blood glucose were lower than those in the control group(P<0.05).There were no significant differences in the levels of CysC and Hcy between the two groups before treatment(P>0.05).The incidence of fetal distress,respiratory distress,macrosomia and the incidence of premature delivery were significantly lower than those of the control group(P<0.05).The amount of insulin in the observation group was less than that in the control group(P<0.05).The level of CysC and Hcy in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Compared with insulin therapy,metformin could improve the outcome of neonatal patients,which might be worthy to be popularized and used in the treatment of gestational diabetes mellitus.
