Effects of benzene and toluene on serum immunological indexes and miRNA-146a,-155 expression in pet-rochemical workers
10.3969/j.issn.1006-5725.2017.10.009
- VernacularTitle:苯和甲苯混合暴露对石化工人血清免疫指标及miRNA-146a,-155表达的影响
- Author:
Qian ZHANG
;
Boxuan LIANG
;
Na DENG
;
Xuexing LIU
;
Qifei DENG
;
Bo ZHANG
;
Xue ZHANG
;
Xiaoju MA
;
Yongmei XIAO
- Keywords:
Benzene and toluene;
Petrochemical workers;
Occupational exposure;
Immunological effects;
miRNA
- From:
The Journal of Practical Medicine
2017;33(10):1564-1567
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of immune system and immuno-related miRNAs expression in low-dose benzene and its homologue mixed-exposed workers in a short time. Methods A total of 40 workers were recruited from a petrochemical factory ,and their blood samples were collected before and after work to detect the levels of IgA,IgG,IgM,IFN-γ,IL-1β,IL-2,IL-8,TNF-αin serum and miRNA-146a,-155 expression in the peripheral blood mononuclear cell. In the meanwhile ,we measured the individual benzene and its homologue exposure level of recruited workers. Results According to the concentration of benzene ,the subjects were divided into benzene-exposed group(20 workers)and control group(20 workers). And toluene exposure level in benzene-exposed group was significantly higher than that in control group(P<0.05). Significant decrease of IgG was found in benzene-exposed workers after one work shift,compared with control group(P<0.05). Moreover,the interaction between benzene and toluene was significant correlated with the decrease of IL-1β and TNF-α(P < 0.05). Additionally,the interaction between miRNA-155 and miRNA-146a was significant correlated with the decrease of TNF-α(P<0.05). Conclusions:Occupational exposure to low-dose benzene and toluene in a short time could decrease immune function. And there may be an effect of miRNAs in the regulation of cytokine.
