The effect of nicorandil and trimetazidine on myocardial microcirculation in patients with NSTEMI after elective PCI

VernacularTitle:尼可地尔联合曲美他嗪对非ST段抬高心肌梗死冠状动脉介入患者心肌微循环的影响
Author: Liye WEI ; Yue XIA ; Guoqing QI ; Zhiyu YANG ; Hongliang ZHAO ; Qingwen ZHANG
Keywords: Acute myocardial infarcfion; Percutaneous coronary intervention; Coronary microvascular; Nicorandil; Trimetazidine
From: The Journal of Practical Medicine 2017;33(9):1483-1486
CountryChina
Language:Chinese
Abstract: Objectives To assess the effect of nicorandil and trimetazidine on myocardial microcirculation reperfusion in patients with NSTEMI after elective PCI. Methods 80 patients with NSTEMI were randomly assigned to four groups: normal medicine group (CON), nicorandil group (NIC), trimetazidine group (TMZ) and Combination group (NIC+TMZ). The coronary angiography and PCI were performed after 10 days. MCE was taken since 72 hours after operation. Results There were no significant differences in baseline characteristics between the four groups (P > 0.05). The A, β and A ·β of group NIC were significantly higher than group CON (P < 0.05). There were no significant differences between the group TMZ and the group CON (P>0.05). The A,βand A·βof group NIC+TMZ were significantly higher than group NIC or TMZ (P<0.05). Conclusions Nicorandil can improve the situation of myocardial reperfusion after elective PCI in patients with NSTEMI, and it has some synergetic effect when combined with trimetazidine.