Changes of nerve function in patients with delayed encephalopathy after acute carbon monoxide poisoning following treatment with ginkgo biloba extract
10.3969/j.issn.1006-5725.2017.10.039
- VernacularTitle:一氧化碳中毒迟发性脑病患者应用银杏叶提取物治疗前后神经功能的变化
- Author:
Weizhan WANG
;
Hongna QI
;
Qingmian XIAO
;
Xun GAO
;
Jing LI
;
Baoyue ZHU
;
Yongjian LIU
;
Wei LI
;
Guoying MA
;
Pu WANG
- Keywords:
Acute severe carbon monoxide poisoning;
Delayed encephalopathy;
Extract of ginkgo biloba;
Magnetic resonance imaging;
Electroencephalography
- From:
The Journal of Practical Medicine
2017;33(10):1677-1681
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact of ginkgo biloba extract(Ginaton) on nerve functioninpa-tients withdelayed encephalopathy after acute carbon monoxide poisoning(DEACMP). Methods 96 patients with DEACMP treated in our hospital from April 2011 to February 2017 were randomly divided into a control group and a study group. The control group received hyperbaric oxygen ,control of intracranial pressure ,and improvement of brain cell metabolism;while the study group receivedintravenous injection of Ginaton 70 mg(adding into 250 mL of 0.9% sodium chloride) once daily fora 2-week therapeutic course. MRIand EEGwere used forexamination in DEACMP patients within 24 h after onset and 14 days after treatment. Changes in MRI and EEG examination , clinical symptoms ,mini-mental state examination (MMSE) score ,Barthel index (BI),and Montreal cognitive assessment(MoCA)were assessed before and after treatment between the two groups. Results The therapy wasef-fective in 39 patients in the study group,with a total effectiveness rate of 81.25%;and in 29 patients in the control group,with a total effectiveness rate of 60.42%. There was significant difference between the two groups (χ2 =5.042,P = 0.025). Inadmission,there were no differences between the two groups in the abnormal signals of MRI,abnormal rate of EEG,and the scores on MMSE,BI,andMoCA(P>0.05). After a 14-day treatment,the abnormal signals of MRI,abnormal rate of EEG,andthe scores on MMSE,BI,and MoCA score were improved better in the study than in the control group(P < 0.05). The MMSE score was negatively correlated with disease severity in DEACMP patients(r=-0.832,P=0.000). Conclusions Early treatment with Ginaton can effectively improvethe cerebral lesions on MR,the abnormal rate of EEG,andthe scores on MMSE,BI,and MoCA. It has certain clinical efficacy.
