The relationship of PALB2 and AR expression in triple negative breast cancer and its clinical significance
10.3969/j.issn.1006-5725.2017.09.005
- VernacularTitle:三阴性乳腺癌PALB2与雄激素受体表达关系及临床意义
- Author:
Weihua JIANG
;
Mingshuai ZHANG
;
Yongtao LI
;
Xiaowen WANG
;
Chenguang ZHANG
;
Lina YI
;
Laiti XUE
;
Jianghua OU
- Keywords:
Triple negative breast cancer;
PALB2;
Androgen receptor;
Clinical significance
- From:
The Journal of Practical Medicine
2017;33(9):1381-1384
- CountryChina
- Language:Chinese
-
Abstract:
Objective Discussion the relationship of PALB2 and AR expression in triple negative breast cancer and its clinical pathological features. Methods The SP immunohistochemical staining was adopted to detect the expression of PALB2 and AR in 178 cases of TNBC, PALB2 divided into two groups according to the expression of different, and to analyze the clinical pathological features and prognostic impact of different AR expression status. Results 178 cases of TNBC, that PALB2 missing expression 47 cases (26.4%), AR expression of 60 cases (33.7%), between of them were negatively correlated (-1≤r<1, P<0.05), in PALB2 negative group, AR expression associated with family history, lymph node metastasis, clinical stage and recurrence and metastasis (P<0.05), and 5-year disease-free survival lower than AR negative expression, Log rank = 4.453, P = 0.035. Conclusion PALB2 negative expression while AR positive expression in TNBC have synergistic effect with disease progression, PALB 2 and AR combined detection may provide a new basis for the prognosis of TNBC interpretation, and recommending take further studies to confirm.
