Expression of phosphorylated protein kinase B1 and human telomere reverse transcriptase in epithelial ovarian carcinoma and their clinical significances
10.3760/cma.j.issn.1006-9801.2017.06.005
- VernacularTitle:磷酸化蛋白激酶B1和人端粒酶反转录酶在卵巢上皮性癌中的表达及其临床意义
- Author:
Yuhuan FENG
;
Jianping YI
;
Ying CHEN
;
Huanyu ZHENG
;
Lihua JING
- Keywords:
Ovarian neoplasms;
Phosphorylase kinase;
Telomerase;
Prognosis
- From:
Cancer Research and Clinic
2017;29(6):378-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of phosphorylated protein kinase B1 (pAkt1) and human telomerase reverse transcriptase (hTERT) in ovarian epithelial carcinoma (EOC) and its relationship with prognosis, and to analyze the correlation between pAkt1 and hTERT expression. Methods 92 patients with EOC in Tangshan Gongren Hospital from January 2012 to December 2016 were selected. The expressions of hTERT and pAkt1 proteins were detected by immunohistochemistry. The relationship between the expressions of pAkt1 and hTERT proteins and their relationship with clinical prognosis were analyzed. Results Of the 92 patients with EOC, 68 cases (73.9 %) had positive expression of pAkt and 52 cases (56.5 %) had positive expression of hTERT. There was no significant correlation between expressions of pAkt1 and hTERT proteins in EOC (r= 0.284, P= 0.633). The expressions of pAkt1 and hTERT proteins were not related with age, tumor pathology type and the International Federation of Gynecology and Obstetrics (FIGO) staging (all P> 0.05), but had significant association with tumor pathology differentiation (χ2= 2.694, P= 0.005; χ2=2.284, P=0.018). The disease-free survival of patients with both pAkt1 and hTERT positive was shorter than that of the other groups (P= 0.013). Conclusion The prognosis of EOC patients with high expression of pAkt1 and hTERT proteins is poor.
