Relationship between the expression of TIP30 and clinico-pathological characteristics in extrahepatic cholangiocarcinoma
10.3969/j.issn.1009-9905.2017.04.007
- VernacularTitle:TIP30表达与肝外胆管癌临床病理特征的关系
- Author:
Jianbo LIN
;
Min CUI
;
Bo SHAO
;
Bo YUAN
;
Gongpan LIU
;
Cunhua SHAO
;
Qiang GUAN
;
Yang ZHANG
;
Huiyu LIU
;
Jiangong LI
- Keywords:
TIP30;
Chola ngiocarcinoma;
Clinico-pathology;
Prognosis
- From:
Chinese Journal of Current Advances in General Surgery
2017;20(4):276-279
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of TIP30 and its relationship with clinico-pathological characteristics in patients with extrahepatic cholangiocarcinoma (ECC).Methods:The expression of TIP30 in 78 cases of ECC tissues and 78 cases of para-cancerous tissues were detected by immunohistochemistry.Results:The positive expression rate of TIP30 was 43.59％ and 75.64％ in ECC tissues and para-cancerous tissues,respectively.Differences were statistically significant (P＜ 0.05).The expression levels of TIP30 were not correlated with age,gender,degree of differentiation and tumor size(P＞0.05),but correlated with lymph node metastasis,distant metastasis and TNM staging(P＜ 0.05).The median overall survival of 78 ECC cases was 14.8 months,and it of TIP30 positive expression cases was 20.3 months,statistically higher than 11.5 months in TIP30 negative expression cases(P＜ 0.01).Conclusion:The downregulation of TIP30 is closely correlated with the development,metastasis and prognosis of ECC.TIP30 may be used as a molecular marker to identify and predict the progression,metastasis and prognosis of ECC.
