Expression of hypoxia-inducible factor 1α and bcl-2 proteins in ovarian serous carcinoma and their significances
10.3760/cma.j.issn.1006-9801.2017.06.008
- VernacularTitle:缺氧诱导因子1α和bcl-2蛋白在卵巢浆液性癌中的表达及其意义
- Author:
Xiaoling WANG
;
Qiulan YANG
;
Huixia ZHENG
;
Hongkun WANG
;
Lina WU
- Keywords:
Ovarian neoplasms;
Hypoxia-inducible factor 1;
alpha subunit;
Genes;
bcl-2;
Prognosis
- From:
Cancer Research and Clinic
2017;29(6):390-393
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of hypoxia-inducible factor 1α (HIF-1α) and bcl-2 ovarian serous carcinoma and their clinical significances. Methods Paraffin specimens including 61 cases of ovarian serous carcinoma and 50 normal ovarian tissues were selected. The expressions of HIF-1α and bcl-2 proteins were detected by immunohistochemical EnVision method and their relationship between them was analyzed. Results The positive rate of HIF-1α and bcl-2 proteins expression in 61 ovarian serous carcinoma was 68.9%and 54.1%, respectively. There was a significant difference between the two groups (χ2=55.381, P< 0.05; χ2= 38.493, P< 0.05). The clinical pathological parameters showed that the positive expression of HIF-1αand bcl-2 proteins were not related with the age (P>0.05). HIF-1αpositive expression was correlated with tumor grades, the state of lymph node metastasis and FIGO stages (χ2=4.931, 25.008, 5.610, P<0.05). Bcl-2 was significantly associated with tumor grades and lymph node metastasis (χ2= 6.956, 33.869, P<0.05), but not with FIGO stages (χ2=3.391, P>0.05). The expression of bcl-2 was positively correlated with HIF-1α in ovarian serous carcinoma (r= 0.304, P= 0.017). Conclusions The expressions of HIF-1α and bcl-2 play a synergic role in the progression of ovarian serous carcinoma. The combined detection of HIF-1αand bcl-2 is effective for patients'prognosis judgment.