Progress in multidrug resistance of gastric cancer
10.3760/cma.j.issn.1006-9801.2017.06.018
- VernacularTitle:胃癌多药耐药研究进展
- Author:
Lulu GUAN
;
Qingfang ZHAO
;
Xiaobing CHEN
- Keywords:
Multidrug resistance;
Epithelial-mesenchymal transition;
Non-coding RNAs;
Gastric neoplasm
- From:
Cancer Research and Clinic
2017;29(6):422-425
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy is one of the main treatments for gastric cancer, but its drug resistance often limits the effectiveness of chemotherapy, leading to treatment failure. Drug resistance can be divided into primary drug resistance and secondary resistance. It has showed that several factors were involved in the multidrug resistance of gastric cancer, including the expression of drug resistance-related proteins, abnormalities of apoptosis-related genes, dysfunction of DNA damage repair, epithelial-mesenchymal transition and non-coding RNA. The solution to improve the efficacy of chemotherapy is to overcome drug resistance or delay drug resistance. This article will explore the progress in multi-drug resistance of gastric cancer.
